Promega Customized Reporter and Fusion Vectors on Addgene
Promega created a robust and growing collection of prebuilt plasmids designed to accelerate experimental design and execution. Our luciferase reporter vectors enable sensitive, quantitative analysis of gene expression. Plasmids incorporating innovative tags such as NanoLuc®, HaloTag®, SmBiT, and LgBiT—used in advanced applications like live-cell protein-protein interaction studies via NanoBRET™ and NanoBiT®, and target engagement assays—are now available from Addgene.
Through our partnership with Addgene, these widely used tools are available to both nonprofit and industry researchers without the need for a material transfer agreement (MTA). As a mission-driven organization, Addgene enhances scientific collaboration by offering expert guidance, educational resources and streamlined material transfer—all designed to simplify logistics and accelerate research.
Search the lists below for your vector of interest. Then click the corresponding link to purchase directly from Addgene. Not sure which assay is right for you? Learn more about these technologies below:
Luciferase Reporter Vectors
Promega's luciferase reporter vectors enable highly sensitive and quantitative measurement of gene expression in mammalian cells. These vectors offer flexibility with multiple luciferase options, facilitating optimized experimental design for your specific application.
Search list for your response element or reporter of interest (e.g., NFAT, Firefly). Don’t see what you’re looking for? Check out our DIY options or custom services.
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| Pathway | Response Element/Promoter | Reporter | Addgene Plasmid ID | Request Details |
|---|---|---|---|---|
| Hedgehog | Gli Response Element (Gli) | Firefly | 236803 | |
| Notch | RBK-Jk Response Element | Firefly | 236804 | |
| PI3K/Akt/MAPK | Myc/Max Response Element | NanoLuc | 236805 | |
| TGFβ | SMAD3/SMAD4 Binding Element (SBE) | NanoLuc | 236807 | |
| TGFβ/BMP | Human DNA-Binding Protein Inhibitor ID-1 Promoter | Firefly | 236808 | |
| T Cell Activation IL-1 | Human IL-2 Promoter | Firefly | 236930 | |
| Ras/MEK1 | Serum Response Element (SRE) | NanoLuc | 236810 | |
| MAPK/JNK | AP1 Response Element (AP1 RE) | NanoLuc | 236811 | |
| JAK/STAT1/IFNγ | IFNγ Activation Site (GAS) Response Element | Firefly | 236813 | |
| Myc | Myc Response Element (Myc) | Firefly | 236815 | |
| ER Stress | ATF4 Response Element (ATF4 ERSE) | Firefly | 236816 | |
| Hypoxia | Hypoxia Response Element | NanoLuc | 236817 | |
| Oxidative Stress | Antioxidant Response Element | NanoLuc | 236818 | |
| JAK/STAT5 IL-3 | STAT5 Response Element | NanoLuc | 236819 | |
| STAT3 | Human G-CSF | Firefly | 236823 | |
| cAMP/PKA | Cyclic AMP Response Element (CRE) | NanoLuc | 236829 | |
| JAK/STAT1/IFNγ | IFNγ Activation Site (GAS) Response Element | NanoLuc | 236921 | |
| RhoA (Ga12/13) | Serum Response Factor Response Element | NanoLuc | 236835 | |
| DNA Damage | p53 Response Element (p53 RE) | NanoLuc | 236920 | |
| T Cell Activation IL-1 | Human IL-2 Promoter | NanoLuc | 236918 |
Protein Fusion Vectors
Promega’s protein fusion vectors encode cutting-edge tags, including NanoLuc®, HaloTag®, SmBiT, and LgBiT, enabling precise detection and tracking of proteins. These vectors facilitate advanced applications such as live-cell protein-protein interaction studies (NanoBRET® and NanoBiT®) and accurate measurement of cellular target engagement.
Search list for your protein or tag of interest (e.g., KRAS, NanoLuc). Don’t see what you’re looking for? Check out our DIY options or custom services.
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| Protein | Tag | Terminus | Addgene Plasmid ID | Request Details |
|---|---|---|---|---|
| NRF2 | LgBiT | C | 237127 | |
| NRF2 | SmBiT | C | 237126 | |
| NRF2 | LgBiT | N | 237125 | |
| NRF2 | SmBiT | N | 237124 | |
| MAFG | LgBiT | N | 237123 | |
| MAFG | SmBiT | N | 237122 | |
| MAFG | LgBiT | C | 237121 | |
| MAFG | SmBiT | N | 237120 | |
| CALM1 | LgBiT | N | 237119 | |
| CALM1/ADC1.1 | LgBiT-SmBiT | Bidirectional | 237118 | |
| AR | LgBiT | N | 237117 | |
| CALM1/ADC1.2 | LgBiT-SmBiT | Bidirectional | 237116 | |
| ADCY8 | SmBiT | N | 237115 | |
| CALM1/ADCY8 | LgBiT-SmBiT | Bidirectional | 237114 | |
| AR | SmBiT | C | 237113 | |
| AR/AR | LgBiT-SmBiT | Bidirectional | 237155 | |
| BCL6 | LgBiT | N | 237112 | |
| BCL6 | SmBiT | N | 237111 | |
| BCL6 | LgBiT | C | 237110 | |
| BCL6 | SmBiT | C | 237109 | |
| NCOR2 | LgBiT | N | 237108 | |
| NCOR2 | SmBiT | N | 237107 | |
| NCOR2 | LgBiT | C | 237106 | |
| NCOR2 | SmBiT | C | 237105 | |
| HER1 | LgBiT | C | 237104 | |
| HER3 | SmBiT | C | 237103 | |
| P2RX7 | SmBiT | C | 237102 | |
| P2RX7 | LgBiT | C | 237101 | |
| CRAF | SmBiT | C | 237100 | |
| PIK3R1 | LgBiT | C | 237098 | |
| PIK3R1 | SmBiT | C | 237097 | |
| PIK3R1 | LgBiT | N | 237096 | |
| PIK3R1 | SmBiT | N | 237095 | |
| PIK3CA | LgBiT | C | 237094 | |
| PIK3CA | SmBiT | C | 237093 | |
| PIK3CA | LgBiT | N | 237092 | |
| PIK3CA | SmBiT | N | 237091 | |
| TUBEs | LgBiT | C | 237088 | |
| TUBEs | LgBiT | N | 237087 | |
| CYBC1 | LgBiT | N | 237086 | |
| CYBB | S | C | 237085 | |
| CYBC1/CYBB | LgBiT-SmBiT | Bidirectional | 237084 | |
| ZNRF3 | SmBiT | C | 237083 | |
| RNF43 | LgBiT | C | 237082 | |
| RNF43 | SmBiT | C | 237081 | |
| ZNRF3 | LgBiT | C | 237080 | |
| KRAS 4B (G12C) | SmBiT | N | 237079 | |
| KRAS 4B (G12C) | LgBiT | N | 237078 | |
| CRAF (RBD-CRD) | SmBiT | C | 237077 | |
| KRAS 4B (G12V) | LgBiT | N | 237076 | |
| BCL9 | SmBiT | C | 237075 | |
| BCL9 | SmBiT | N | 237074 | |
| BCL9 | LgBiT | C | 237073 | |
| BCL9 | LgBiT | N | 237072 | |
| Beta catenin | SmBiT | C | 237071 | |
| Beta catenin | SmBiT | N | 237070 | |
| Beta catenin | LgBiT | C | 237069 | |
| Beta catenin | LgBiT | N | 237068 | |
| KRAS (G12V)/CRAF (RBD) | LgBiT-SmBiT | Bidirectional | 237067 | |
| KRAS (WT)/CRAF (RBD) | LgBiT-SmBiT | Bidirectional | 237066 | |
| PDE4C3 | LgBiT | N | 237064 | |
| NRAS | SmBiT | N | 237063 | |
| NRAS | LgBiT | N | 237062 | |
| NRAS (Q61R) | SmBiT | N | 237061 | |
| NRAS (Q61R) | LgBiT | N | 237060 | |
| CYBA/CYBB | LgBiT-SmBiT | Bidirectional | 237059 | |
| VPS4A | SmBiT | N | 237058 | |
| VPS4A | SmBiT | C | 237057 | |
| VPS4B | SmBiT | N | 237056 | |
| VPS4B | SmBiT | C | 237055 | |
| CHMP4B | LgBiT | N | 237054 | |
| CHMP4B | LgBiT | C | 237053 | |
| PPP1CA | SmBiT | N | 237052 | |
| PPP1CA | SmBiT | C | 237051 | |
| PPP1CA | LgBiT | C | 237049 | |
| SELENOP | SmBiT-HaloTag | C | 237048 | |
| KRAS (G12D) | SmBiT | N | 237047 | |
| H3.3 | SmBiT | N | 237046 | |
| H4 | SmBiT | N | 237045 | |
| b4GALT1 | LgBiT | N | 237044 | |
| b4GALT1 | SmBiT | N | 237043 | |
| SLC35A2 | SmBiT | N | 237042 | |
| SLC35A2 | SmBiT | C | 237041 | |
| SLC35A2 | LgBiT | N | 237040 | |
| SLC35A2 | LgBiT | C | 237039 | |
| CHRM1 | LgBiT | C | 236795 | |
| CHRM1 | SmBiT | C | 236796 | |
| MDM2 | SmBiT | N | 237037 | |
| p53 | LgBiT | N | 237036 | |
| cMyc | LgBiT | C | 237035 | |
| Max | SmBiT | C | 237034 | |
| KRAS (G12D) | LgBiT | N | 237033 | |
| CRAF RBD | SmBiT | N | 237032 | |
| KRAS 4B (G12D) | SmBiT | N | 236798 | |
| CRAF (FL) | LgBiT | N | 236799 | |
| GLP-1R | SmBiT | C | 236845 | |
| ERN1 | SmBiT | N | 237030 | |
| GR | SmBiT | C | 237159 | |
| GR | LgBiT | N | 237160 | |
| CD3E | LgBiT | C | 237029 | |
| CD3E | SmBiT | C | 237028 | |
| NCK1 | LgBiT | C | 237027 | |
| NCK1 | SmBiT | C | 237026 | |
| NCK1 | LgBiT | N | 237025 | |
| NCK1 | SmBiT | N | 237024 | |
| YAP1 | NanoLuc | C | 237023 | |
| GR | HaloTag | N | 237153 | |
| GR | NanoLuc | C | 237154 | |
| PD-L1 | HaloTag | C | 237128 | |
| PD-L1 | NanoLuc | C | 237129 | |
| MAVS/IFIH1 | NanoLuc-HaloTag | Bidirectional | 237022 | |
| E6 | HaloTag | C | 237133 | |
| E6AP | NanoLuc | C | 237134 | |
| MLL1 | NanoLuc | N | 237135 | |
| Menin | HaloTag | N | 237136 | |
| BCL9L | HaloTag | C | 237137 | |
| beta-Catenin | NanoLuc | N | 237138 | |
| EED | NanoLuc | C | 237130 | |
| PRMT5 | NanoLuc | C | 237131 | |
| TAF1 | NanoLuc | C | 237132 | |
| ACT1 | NanoLuc | N | 237018 | |
| ACT1 | NanoLuc | C | 237017 | |
| PD-1/SHP2 | NanoLuc-HaloTag | Bidirectional | 237016 | |
| TCF4 | NanoLuc | N | 237015 | |
| beta-Catenin | HaloTag | C | 237014 | |
| Histone H4 | HaloTag | C | 237011 | |
| MLL1 | NanoLuc | C | 237139 | |
| WDR5 | HaloTag | C | 237140 | |
| BCL9L | HaloTag | N | 237010 | |
| NSD3 | NanoLuc | C | 237008 | |
| WDR5 | HaloTag | N | 237141 | |
| MYC | NanoLuc | C | 237142 | |
| VCP | HaloTag | N | 237006 | |
| VCP | HaloTag | C | 237005 | |
| TEAD4 | HaloTag | C | 237004 | |
| YAP1/TEAD4 | NanoLuc-HaloTag | Bidirectional | 237003 | |
| PRMT5 | NanoLuc | N | 237002 | |
| CSNK1A1 | NanoLuc | C | 237143 | |
| E-cadherin | HaloTag | C | 237144 | |
| APC | HaloTag | N | 237145 | |
| MAFG | HaloTag | N | 237001 | |
| WRN | NanoLuc | N | 237000 | |
| WRN | NanoLuc | C | 236999 | |
| BCL9 | NanoLuc | C | 237146 | |
| beta-Catenin | HaloTag | N | 237147 | |
| FBXO42 | HaloTag | C | 236998 | |
| FBXO42 | HaloTag | N | 236997 | |
| FBXO42 | NanoLuc | C | 236996 | |
| FBXO42 | NanoLuc | N | 236995 | |
| CCDC6 | HaloTag | C | 236994 | |
| CCDC6 | HaloTag | N | 236993 | |
| CCDC6 | NanoLuc | C | 236992 | |
| CCDC6 | NanoLuc | N | 236991 | |
| beta-Catenin (S45F) | HaloTag | C | 236990 | |
| TREM2 | HaloTag | C | 237148 | |
| IRF5 | HaloTag | C | 237149 | |
| IRF5 | NanoLuc | C | 237150 | |
| CKS1B | HaloTag | N | 237151 | |
| Skp2 | NanoLuc | C | 237152 | |
| TEAD2 | NanoLuc | C | 236987 | |
| TEAD3 | NanoLuc | C | 236986 | |
| MDM4 | NanoLuc | N | 236985 | |
| FKBP-12 | NanoLuc | C | 236984 | |
| FKBP-12 | NanoLuc | N | 236983 | |
| PPP3CA | HaloTag | C | 236982 | |
| PPP3CA | HaloTag | N | 236981 | |
| hVPS4A | NanoLuc | N | 236980 | |
| hVPS4A | NanoLuc | C | 236979 | |
| hVPS4A | HaloTag | N | 236978 | |
| hVPS4A | HaloTag | C | 236977 | |
| hVPS4B | HaloTag | N | 236976 | |
| hVPS4B | HaloTag | C | 236975 | |
| hCHMP4B | NanoLuc | N | 236974 | |
| hCHMP4B | NanoLuc | C | 236973 | |
| hCHMP4B | HaloTag | N | 236972 | |
| hCHMP4B | HaloTag | C | 236971 | |
| hVTA1 | NanoLuc | N | 236970 | |
| hVTA1 | NanoLuc | C | 236969 | |
| hVTA1 | HaloTag | N | 236968 | |
| hVTA1 | HaloTag | C | 236967 | |
| FBXO22 | HaloTag | C | 236966 | |
| MBP | HaloTag | N | 236965 | |
| MBP | HaloTag | C | 236964 | |
| MBP | NanoLuc | N | 236963 | |
| MBP | NanoLuc | C | 236962 | |
| FYN | HaloTag | N | 236961 | |
| FYN | HaloTag | C | 236960 | |
| FYN | NanoLuc | N | 236959 | |
| VDR | NanoLuc | C | 236958 | |
| VDR | NanoLuc | N | 236957 | |
| E-cadherin1 | NanoLuc | C | 236956 | |
| TTC7B | HaloTag | N | 236955 | |
| TTC7B | HaloTag | C | 236954 | |
| TTC7B | NanoLuc | N | 236953 | |
| TTC7B | NanoLuc | C | 236952 | |
| PP1Cg | HalTag | N | 236951 | |
| PP1Cg | HaloTag | C | 236950 | |
| PP1Cg | NanoLuc | N | 236949 | |
| PP1Cg | NanoLuc | C | 236948 | |
| SHOC2 | NanoLuc | N | 236947 | |
| CBP (bd1) | NanoLuc | C | 236945 | |
| FANCD2 (WT) | NanoLuc | N | 236944 | |
| Ubiquitin | HaloTag | N | 236943 | |
| TEAD1 | HaloTag | C | 236942 | |
| TEAD2 | HaloTag | C | 236941 | |
| TEAD3 | HaloTag | C | 236940 | |
| YAP | NanoLuc | N | 236938 | |
| TAZ | NanoLuc | N | 236937 | |
| KSR1 | HaloTag | C | 236794 | |
| KSR2 | HaloTag | C | 236793 | |
| TP53 (Y220C) | TP53(Y220C) | C | 236802 | |
| IRF5 | HaloTag | C | 236791 | |
| IRF5 | NanoLuc | C | 236792 | |
| MALT1 | NanoLuc | N | 236936 | |
| MALT1 | NanoLuc | C | 236935 | |
| EZH2 | NanoLuc | C | 236934 | |
| Suz12 | HaloTag | N | 236933 | |
| ER | HaloTag | C | 236932 | |
| ER | NanoLuc | C | 236931 | |
| BRAF (RBD) | HaloTag | C | 236879 | |
| KRAS (WT) | NanoLuc | N | 236878 | |
| ARAF | HaloTag | C | 236877 | |
| ARAF | NanoLuc | C | 236876 | |
| NRAS (WT) | NanoLuc | N | 236875 | |
| CRAF (FL) | HaloTag | C | 236874 | |
| CRAF (RBD-CRD) | HaloTag | C | 236873 | |
| CRAF (CRD-RBD)/KRAS (G12C) | NanoLuc-HaloTag | Bidirectional | 236872 | |
| KRAS | HaloTag | N | 236871 | |
| CRAF (FL) | NanoLuc | C | 236870 | |
| KRAS (G12C)/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236869 | |
| KRAS (G12C)/CRAF (FL) | NanoLuc-HaloTag | Bidirectional | 236868 | |
| KRAS (G12D)/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236867 | |
| HRAS (WT) | nan | nan | 236866 | |
| KRAS (WT)/CRAF (RBD-CRD) | NanoLuc-HaloTag | Bidirectional | 236865 | |
| NRAS/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236864 | |
| NRAS (Q61R) | NanoLuc | N | 236863 | |
| NRAS (Q61R)/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236862 | |
| HRAS (WT)/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236861 | |
| NRAS (Q61K)/CRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236860 | |
| KRAS (G12V) | NanoLuc | N | 236859 | |
| KRAS (G12C) | HaloTag | N | 236858 | |
| KRAS (G12D) | HaloTag | N | 236857 | |
| KRAS (G13D) | HaloTag | N | 236856 | |
| PIK3CA | NanoLuc | N | 236855 | |
| NRAS (Q61K) | NanoLuc | N | 236854 | |
| KRAS (2B WT)/BRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236853 | |
| NRAS (Q61R)/BRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236852 | |
| NRAS (WT)/BRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236851 | |
| HRAS (WT)/BRAF (RBD) | NanoLuc-HaloTag | Bidirectional | 236850 | |
| SOS1 | NanoLuc | N | 236848 | |
| XIAP | NanoLuc | N | 237212 | |
| UHMK1 | NanoLuc | N | 237211 | |
| DGKb | NanoLuc | C | 237163 | |
| DGKb | NanoLuc | N | 237186 | |
| DGKb | NanoLuc | C | 237167 | |
| KDR | NanoLuc | C | 237210 | |
| TOM7 | NanoLuc | N | 237166 | |
| TOM20 | NanoLuc | C | 237179 | |
| TOM20 | NanoLuc | N | 237174 | |
| PNCK | NanoLuc | C | 237209 | |
| HSD17B13 | NanoLuc | N | 237180 | |
| HSD17B13 | NanoLuc | C | 237170 | |
| IRAK2 | NanoLuc | N | 237181 | |
| EGR2 | NanoLuc | N | 237171 | |
| PTPN2 | NanoLuc | N | 237182 | |
| PGDH | NanoLuc | C | 237184 | |
| PGDH | NanoLuc | N | 237177 | |
| EIF2AK3 | NanoLuc | C | 237169 | |
| EIF2AK3 | NanoLuc | N | 237188 | |
| KSR1 | NanoLuc | C | 237175 | |
| AKT3 | NanoLuc | C | 237208 | |
| BRD9 (BD) | NanoLuc | N | 237205 | |
| BRPF1 (BD) | NanoLuc | N | 237204 | |
| CECR2 (BD) | NanoLuc | N | 237203 | |
| TAF1 | NanoLuc | N | 237165 | |
| TAF1 | NanoLuc | N | 237201 | |
| CA2 | NanoLuc | N | 237187 | |
| CA2 | NanoLuc | C | 237164 | |
| EIF2AK2 (252-551) | NanoLuc | C | 237172 | |
| EGFR (L858R T790M) | NanoLuc | C | 237199 | |
| SRPK1 | NanoLuc | C | 237178 | |
| MDM2 | NanoLuc | N | 237198 | |
| PI4KB | NanoLuc | C | 237197 | |
| HSP90AB1 | NanoLuc | N | 237196 | |
| cIAP1 | NanoLuc | N | 237195 | |
| DCLK1 (Iso1) | NanoLuc | C | 237193 | |
| CIT | NanoLuc | N | 237191 | |
| TGFBR1 | NanoLuc | C | 237190 | |
| NLRP3 | NanoLuc | C | 237189 | |
| DSTYK | NanoLuc | N | 237162 | |
| TP53 (Y220C) | HiBiT | N | 236914 | |
| GCGR | secHiBiT | N | 236837 | |
| TP53 | HiBiT | C | 236838 | |
| SRPK1 | HiBiT | N | 236908 | |
| WRN | HiBiT | N | 236906 | |
| WRN | HiBiT | C | 236905 | |
| CLK3 | HiBiT | N | 236904 | |
| CLK3 | HiBiT | C | 236903 | |
| IFIH1 | HiBiT | C | 236902 | |
| IFIH1 | HiBiT | N | 236901 | |
| Beclin-1 | HiBiT | N | 236900 | |
| Beclin-1 | HiBiT | C | 236899 | |
| CHRM1 | HiBiT | N | 236898 | |
| SHOC2 | HiBiT | N | 236897 | |
| UBASH3A | HiBiT | C | 236896 | |
| ADAR | HiBiT | C | 236895 | |
| VPS4A | HiBiT | N | 236894 | |
| VPS4B | HiBiT | N | 236893 | |
| ADARB1 | HiBiT | C | 236892 | |
| TDP1 | HiBiT | N | 236891 | |
| CFTR (WT) | HiBiT | C | 236890 | |
| BRPF1 | NanoLuc | C | 236889 | |
| KDR | secHiBiT | N | 236888 | |
| SLC35A2 | HiBiT | N | 236887 | |
| SLC35A2 | HiBiT | C | 236886 | |
| TP53 | HiBiT | N | 236885 | |
| IRAK4 | HiBiT | N | 236884 | |
| HRH2 | HiBiT | N | 236883 | |
| HSD17B13 | HiBiT | N | 236839 | |
| HSD17B13 | HiBiT | C | 236840 |