The Dual-Luciferase® Reporter Assay System is a robust, simple and very sensitive assay system used to measure two luciferase activities simultaneously from a single sample. Proprietary technology has increased Renilla luciferase sensitivity by lowering the enzyme-independent luminescence in the Renilla luciferase portion of the assay.
Promega Notes 85, 31–33.
Erika Hawkins, Michael Beck, Braeden Butler and Keith Wood